Glyoxal thiosemicarbazone

Bis(thiosemicarbazones) [89-97] and AT-heterocyclic thiosemicarbazones comprise two interesting series of experimental chemotherapeutic agents. 2-formylpyridine thiosemicarbazone, the first of the latter series to be examined for biological activity, showed mild antileukemic activity against 1-1210 tumor in mice [98]. However, it was found to be toxic at the therapeutic dose levels which led to synthesis of other aromatic and heterocyclic thiosemicarbazones as potential agents [80, 99, 100]. However, the only active anticancer compounds besides glyoxal bis(thiosemicarbazones) were the iV-heterocyclic thiosemicarbazones [101], 2 formyl-3-hydroxypyridine thiosemicarbazone [102] and... 

Table 58 gives the formation constants for silver(I) complexes of acetone thiosemicarbazone and glyoxal dithiosemicarbazone (55).443 In the latter case, the ligand was found to be suitable for the photometric determination of silver at pH 1 1, in the presence of EDTA. The effective molar absorptivity was 43 000 cm2 mmol-1 at 335 nm.443... 

Glyoxal bis(2-mercaptoanil), G-00029 Glyoxal bis(thiosemicarbazone), G-00034 Hexabutylphosphorothioic triamide, in H-00020... 

Glyoxal bis(2-hydroxyanil), G-00027 Glyoxal bis[4-(6-methyl-2-benzothiazolyl) phenyl]thiosemicarbazone, G-00030 Glyoxal bis( 1 -naphthylthiosemicarbazone), G-00031 Glyoxal bis(4-... 

Glyoxal bis[4-(2-trifluoromethyl)phenyl] thiosemicarbazone, G-00036 4,4 -Heptylidenebis[ 1,2-dihydro-1,5-dimethyl-2-phenyl-3//-pyrazole-3-thione], H-00017... 

Glyoxal bis(thiosemicarbazone), G-00034 Glyoxal bis[4-(3-trifluoromethyl)-4-chlorophenyl] thiosemicarbazone, G-00035... 

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