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Glycosylations, with transferases sialylation

The synthetic utilities of sialyltransferases as alternative methods to sialylate oligosaccharide and glycoconjugates have been further explored by Halcomb who described the synthesis of a novel anomeric sulfur analogue of CMP-sialic acid (103). The key step in the synthesis of this novel CMP-sialic acid was a tetrazole-promoted coupling of a cytidine-5 -phosphoramidite with a glycosyl thiol of a protected sialic acid. The rate of solvolysis of (103) in aqueous buffer was reported to be 50-fold slower than that of CMP-sialic acid. Thioester (103) was a substrate for the transferase with a three-fold higher than the of the... [Pg.189]

See other pages where Glycosylations, with transferases sialylation is mentioned: [Pg.1780]    [Pg.449]    [Pg.330]    [Pg.592]    [Pg.38]    [Pg.2284]    [Pg.2656]    [Pg.883]    [Pg.199]    [Pg.553]    [Pg.611]    [Pg.611]    [Pg.1398]    [Pg.1029]    [Pg.97]    [Pg.447]    [Pg.63]    [Pg.240]    [Pg.41]    [Pg.367]    [Pg.507]    [Pg.515]    [Pg.233]    [Pg.141]    [Pg.307]    [Pg.211]    [Pg.224]    [Pg.601]    [Pg.712]    [Pg.730]    [Pg.334]   
See also in sourсe #XX -- [ Pg.223 , Pg.224 , Pg.225 , Pg.226 , Pg.227 , Pg.228 , Pg.229 , Pg.230 ]



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Glycosyl transferases

Glycosylation sialylation

Glycosylation with transferases

Sialyl

Sialyl transferases

Sialylated

Sialylation

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