Glycosylations dimethyl sulfonium trifluoromethanesulfonate

Notes and discussion. Coupling reactions that exploit the methylthioglycoside of a-(2 —> 3)sialyl-galactose derivative have produced a number of sialo-oligosacchar-ides to date. For glycosylations with less reactive acceptors, activation by the action of dimethyl(methylthio)sulfonium trifluoromethanesulfonate is considered to be more feasible. Recently the corresponding trichloroacetimidate donor has also been utilized. 

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