Glycosylation intracellular proteins

Intracellular Glycosylation Intracellular Protein Traffkking Antigen Presentation and Viral Glycosylation Secreted Glycoproteins... 

Carbohydrates are linked to some soluble proteins as well as membrane proteins. In particular, many of the proteins secreted from cells are glycosylated. Most proteins present in the serum component of blood are glycoproteins (Figure 11.20). Furthermore, A-acetylglucosamine residues are O-linked to some intracellular proteins. The role of these carbohydrates, which are dynamically added and removed, is under active investigation. 

The intracellular protein-making machinery first of all produces polypeptide a-chains (approximately 1000 amino acids). Some of the prolyl and lysyl residues are hydroxylated by reactions that need vitamin C (Chapter 56). Some of the hydroxylysyl residues are glycosylated. The units then associate to form the triple helix (rope-like) procollagen, which is soluble. 

Glycosylation Is Important for Protein Folding and Intracellular Transport... 

---