Glycosyl reactivity patterns

Reactivity Patterns and Some Useful Reactions of Glycosyl Bromides 68... 

Firstly, the reactivity of the glycosyl donor can be varied over wide ranges by the choice of the halogen, the protecting group pattern, the catalyst, the solvent and the temperature. In this way the glycosyl donor reactivity can be adjusted to the glycosyl acceptor reactivity (which can also be varied). 

Serum and synovial fluid have been obtained at the same time from 22 patients with rheumatoid arthritis and analyzed for microheterogeneity of a 1-acid-glycoprotein [16]. In most samples the glycosylation pattern was similar, a nonreactive variant and two Con A reactive variants (the first and the second). In seven samples of synovial fluid an extra third peak was observed representative of the fraction strongly reactive with Con A. 

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