Glycogen metabolism regulatory cascade

Thus, cAMP stimulates a kinase cascade that phosphorylates the regulatory enzymes of glycogen metabolism. It simultaneously activates PI-1, which converts PP-1 to the inactive form. Conversely, action of insulin stimulates phosphatase activity in cells, completely reversing the kinase cascade and reversing the preferred activities of the glycogen metabolism enzymes. 

Mechanisms. cAMP plays a central role as a second messenger in the regulation of cell metabolism (14). Binding of cAMP with the regulatory subunit of a protein kinase initiates a cascade of enzymatic reactions that ultimately lead to the breakdown of glycogen and release of glucose to the blood stream. The intracellular concentration of cAMP represents a balance between the action of adenylate cyclase (which produces cAMP... 

---