Glycogen metabolism glycogenolysis

When bound to calcium, calmodulin plays a special role as an integral subunit of the glycogen metabolism enzyme, phosphorylase b kinase. Hence, the glycogenolysis cascade depends on intracellular calcium concentration as well as on cyclic AMP levels. This dependence is particularly... 

There were also less concrete considerations. In the early 1950s glycogenolysis was still believed to be completely reversible. UTP dependency and the glycogen synthase reactions had not yet been discovered nor had phosphofructokinase been shown to act irreversibly. The mechanism of protein synthesis was still a mystery. Laboratories studying proteolysis had shown that the peptide bond could be resynthesized by peptidases, although under very restricted conditions. Reversibility seemed to be an accepted property of the major metabolic pathways. 

Metabolic effects. P-Receptors mediate increased conversion of glycogen to glucose (glycogenolysis) in both liver and skeletal muscle. From the liver, glucose is released into the blood. In adipose tissue, triglycerides are hydrolyzed to fatty acids lipolysis, mediated by P3-receptors), which then enter the blood (C). The metabolic effects of catecholamines are not amenable to therapeutic use. 

C. As glucose is consumed by cellular metabolism, glycogen is degraded (glycogenolysis) to form free glucose in an effort to maintain relatively constant blood glucose levels. 

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