Glycogen hepatic storage

Amalfitano, A., Yie-Wylie, A. J., Hu, H., Dawson, T. L., Raben, N., Plotz, P. and Chen, Y. T. (1999). Systemic correction of the muscle disorder glycogen storage disease type II after hepatic targeting of a modified adenovirus vector encoding human acid-alpha-glucosidase. Proc. Natl. Acad. Sci. USA 96, 8861-8866. 

Lee, R, Mather, S., Owens, X, Leonard, X, Dicksmireaux, C. Hepatic ultrasound findings in the glycogen storage diseases. Brit. X Radiol. 1994 67 1062-1066... 

Because the liver is a major processor of dietary and endogenous carbohydrates, liver disease affects carbohydrate metabolism in a variety of ways (see Chapter 25). However, none of the conventional modes of evaluating carbohydrate metabolism have value in the diagnosis of liver disease. Because the liver is the major site of both glycogen storage and gluconeogenesis, hypoglycemia is a common complication in certain liver diseases, particularly Reye s syndrome, fulminant hepatic failure, advanced cirrhosis, and hepatocellular carcinoma. 

A direct stimulatory effect on hepatic glycogenolysis Pj) mediated by cAMP-dependent phosphorylation of phosphorylase. This effect is dependent on prior storage of glycogen in the liver therefore, both insulin and cortisol serve to condition the liver for this effect. 

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