Glycogen bulk synthesis

Figure 1. Pathway of glycogen synthesis. The two stages are initiation mediated by glycogenin (GN) and bulk synthesis catalyzed by glycogen synthase and the branching enzyme.

The major fuels of skeletal muscle are glucose and fatty acids. Because of the enormous bulk, skeletal muscle is the body s major consumer of fuel. After a meal, under the influence of insulin, skeletal muscle takes up glucose to replenish glycogen stores and amino acids that are used for protein synthesis. Both excess glucose and amino acids can also be oxidized for energy. 

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