Glycoconjugates measurement

In order to elucidate the extended glycoconjugate binding specifities of MAG and other siglecs (Schwann cell myelin protein [SMP] and sialoadhesin [Sn]), Schnaar et al. [26a,27b] measured the siglec-mediated half-maximal cell adhesion to several immobilized natural and synthetically modified gangliosides (Table 16.2) [29]. 

Table 2 Binding of the Human Natural Polyclonal anti-Gal Antibody IgG to a-gal-Mannose Glycoconjugates as Measured by ELISA...

Changes were noted on glycolipid synthesis effects on synthesis of other glycoconjugates were not measured, f Variable reductions in saturation densitv were observed... 

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