Glycine benzyl ester

C2H5NO2 56-40-6) see Eptifibatide Levodopa Loprazolam Stepronin Tiopronin glycine benzyl ester tosylate (CijHijNOjS 1738-76-7) see Acetorphan glycine potassium salt... 

Preparation of the tripeptide component is outlined in Scheme 2. The glycine benzyl ester was coupled to commercially available f-Boc-glycine using 1,1-carbonyldiimidazole as coupling agent. Removal of the carbamate on the N-terminus (TFA) furnished 4 in 90% yield (two steps). Compound 4 was coupled... 

The O-benzylated aldehyde 517 was also coiu erted into the a,p-unsaturated ester 522 through Wadsworth-Emmons reactioiT-- with ethyl 2-(diethoxyphosphono)acetate5 ° in excellent yield (Scheme 88). The intermediate alkene 522 was subjected to Sharpless asymmetric dihydroxylalion " to afford the diol ester 523 in excellent yield and with a diastereoselectivity in excess of 95 5. Subsequent to alkali-catalyzed hydrolysis of 523, the carboxylic acid obtained was condensed with the p-lolucncsulfonalc salt of glycine benzyl ester or phenylalanine benzyl ester, by the action of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC), to afford the benzyl-protected amide derivatives catalytic... 

Through the observation of proton-decoupled 15N NMR lineshapes of two crystalline phases of Boc-glycylglycyl[15N,2H]glycine benzyl ester, the 15N-2H bond length and the direction of the most deshielded component of the shielding tensor, an, have been determined, combined with X-ray diffraction data.32... 

GLYCINE. N-CARBOXY-, ACETONYL ESTER, N-BENZYL ESTER... 

Scheme 8 Asymmetric alkylation of N-(diphenylmethylene)glycine isopropyl ester with benzyl bromide catalyzed by the dendronized catalysts shown in Fig. 25...

Peptide synthesis, The condensation of the tetrabutylammonium salt of N-benzyl-L-leudne (2) with glycine ethyl ester (3), the components in the Young test, in DMF in the presence of 1 as coupling reagent proceeds in 75-80% yield without racemization. 

Step [2] Protect the COOH group of glycine as a benzyl ester. 

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