Glycidic ester, condensation synthesis

Benzilic acid rearrangement Benzoin reaction (condensation) Blanc chloromethylation reaction Bouveault-Blanc reduction Bucherer hydantoin synthesis Bucherer reaction Cannizzaro reaction Claisen aldoi condensation Claisen condensation Claisen-Schmidt reaction. Clemmensen reduction Darzens glycidic ester condensation Diazoamino-aminoazo rearrangement Dieckmann reaction Diels-Alder reaction Doebner reaction Erlenmeyer azlactone synthesis Fischer indole synthesis Fischer-Speior esterification Friedel-Crafts reaction... [Pg.1210]

Rosen, T. Darzens Glycidic Ester Condensation In Comprehensive Organic Synthesis Trost, B. M. Fleming, I., Eds. Pergamon Oxford, 1991, vol. 2, pp 409-439. (Review). [Pg.184]

Allen and Van Allen, Org. Syntheses, 24, 82 (1944). For a review of the Darzens glycidic ester condensation of which this synthesis is an example, see Magerlein in Adams Organic Reactions, Vol. V, p. 413, John Wiley and Sons, Inc., New York, 1949. [Pg.219]

The Darzens glycidic ester condensation involves the condensation of an aldehyde or ketone with an a-halo ester, in the presence of a base, to afford an a,3 epoxy ester (a glycidic ester ). The first synthesis of a glycidic ester was reported by Erlenmeyer in 1892 and is illustrative of the general reaction, as shown in equation (1). The reaction was subsequently developed and generalized by Darzens. Glycidic esters, in addition to undergoing transformations normally associated with epoxides, afford upon hydro-... [Pg.409]