Glycerol parenteral preparations

Thus, an increase in viscosity, leading to a reduced quenching rate constant (Equation 14.8), will result in an increased lifetime of the reactive intermediate (Equation 14.9). Depending on the nature of the diffusion-controlled reaction and the reactivity of the products formed, a rise in viscosity by addition of cosolvents like glycerol to the parenteral preparation can lead to improved or reduced photochemical... 

A. Parenteral. Propofol (Diprivan) 1% (10 mg/mL) emulsion in 10% soybean oil with 2.25% glycerol and 1.25% purified egg phospholipid in 20-, 50-, or 100-mL vials and a 50-mL prefilled syringe. Contains disodium EDTA or sodium metabisulfite in the US formulation as preservatives. A 2% (20 mg/mL) emulsion has been formulated to provide the same amount of drug with less lipid concentration, but is not yet approved in the United States. Note Propofol is provided as a ready-to-use preparation, but if dilution is necessary, only use D5W and don t dilute to conoentrations less than 2 mg/mL. 

---