Gelatin glycerin

Suppositories are conical or ovoid shape solid preparation made up of fat (cocoa butter oil or theobroma oil), a wax or a glycerine-gelatin jelly. They are used for insertion into the rectum, where they melt, dissolve and disperse and exert their action - local as well as systemic. 

The use of water-soluble bases may result in some irritation because, as they take up water and dissolve, they may produce slight dehydration of the rectal mucosa. They are widely used, however, and release the drug by dissolving and mixing with the aqueous body fluids. PEG suppository bases and glycerinated gelatin are the most popular in this class. 

Glycerin-Gelatin becomes solid when cool. For use warm the bottle in a water Bath after first removing the stopper. A glass rod... 

If the objects or sections are such as not to he liable to shrink they can be transferred from water directly to glycerin-gelatin. 

FIRST AID rinse eyes immediately with large amounts of water for several minutes rinse and wash affeeted areas of skin with plenty of soap and water upon inhalation, move exposed person to fresh air if swallowed, drinking glycerin, gelatin solutions, or large volumes of water may delay hardening. 

In the past a glycerinated gelatin base was often used for pessaries. Glycerinated gelatin pessaries provide at body temperature a good adhesive, softened mass and they are tolerated weU. Because of many disadvantages however (see Sect. 11.4.3), this base is not used anymore in Dutch pharmacies. 

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