Glycerin, diuretic effects

Glycerin Suppository [Laxative] Uses Constipation Action Hyperosmolar laxative Dose Adults. 1 adult supp PR PRN Feds. 1 infant supp PR daily-bid PRN Caution [C, ] Disp Supp SE D Interactions T Effects W/ diuretics EMS Monitor ECG and BP for signs of hypovolemia and electrolyte disturbances d/t D OD Unlikely but may cause severe D and dehydration symptomatic and supportive... 

Osmotic diuretics are used cautiously in patients with renal or kidney imi>airment or electrolyte imbalance. The osmotic diuretics are Rregnancy Cat iy B (isosorbide) and C (glycerin, mannitol, and urea) dru and must be used cautiously during pr iancy and lactation. Additive hypotensive effects occur when the osmotic diuretics are given witli otlier antihyiiertensive drugs or nitrate. 

Prototypes and Mechanism of Action Mannitol, the prototypical osmotic diuretic, is given intravenously. Other drugs often classified with mannitol (but rarely used) include glycerin, isosorbide, and urea. Because it is freely filtered at the glomerulus but poorly reabsorbed from the tubule, mannitol remains in the lumen and holds water by virtue of its osmotic effect. The major location for this action is the proximal convoluted mbule, where the bulk of isosmotic reabsorption normally takes place. Reabsorption of water is also reduced in the descending limb of the loop of Henle and the collecting tubule. 

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