Glyceraldehydephosphate dehydrogenase

There are other hydrolytic enzymes, such as lipases (see below) and alkaline phosphatase, with a mechanism closely related to that of the serine proteases or glyceraldehydephosphate dehydrogenase (GAP-DH) containing a cysteine in the active site. 

Fig. 44. Degradation of glucose by the Embden-Meyerhof-Parnas pathway 1 Hexokinase 2 glucosephosphate isomerase 3 6-phosphofructokinase 4 fructose-bisphosphate aldolase 5 triosephosphate isomerase 6 glyceraldehydephosphate dehydrogenase phospho-glycerate kinase 7 phosphoglyceromutase 8 enolase 9 pyruvate kinase...

The mechanism of action of glyceraldehydephosphate dehydrogenase, the enzyme that eatalyses the synthesis of the acyl phosphate, is not, however, a closed book. It continues to fascinate a select band of biochemists, who simply refer to it as the enzyme , and this research has been given a new dimension by the recently published three-dimensional structure. 

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