Glutathione, with peroxidized lipids

This selenium-dependent enzyme [EC 1.11.1.9] catalyzes the reaction of two molecules of glutathione with hydrogen peroxide to produce glutathione disulfide and two water molecules. Hydrogen peroxide can be replaced by steroid and lipid hydroperoxides, albeit not as effectively (nevertheless, this enzyme is not identical with phospholipid-hydroperoxide glutathione peroxidase [EC 1.11.1.12]). However, the hydroperoxy products formed by the action of lipoxygenase [EC 1.13.11.12] are not substrates. 

Fig. 1.9. Effects of sesquiterpene lactones on European corn borer, (a) Glutathione levels (b) lipid peroxidation synergistic effects of-terthienyl (c) with sesquiterpene lactones from the Asteraceae on larval mortality. Means followed by the same letter are not significantly different in Tukey s test (P < 0.05).

B31. Bruns, C. M., Hubatsch, I., Ridderstrom, M., Mannervik, B., and Tainer, J. A., Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. J. Mol. Biol. 288, 427 139 (1999). 

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