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Glutathione -responsive polymers

El-Sayed MEH, Hoffmann AS, Stayton PS. Rational design of composition and activity correlations for pH-responsive and glutathione-reactive polymer therapeutics. J Control Release 2005 104 417 27. [Pg.285]

Wang J, Zheng Z, Chen L, Tu X, Wang X. Glutathione-responsive biodegradable poly(urea-urethane)s containing L-cystine-based chain extender. J Biomater Sci Polym Ed 2013 24(7) 831 8. [Pg.168]

In a study, polymeric nanoparticles (NPs) composed of a new redox-responsive polymer, poly(ethylene glycol]-b-poly(lactic acid] [MPEG-SS-PLA], were prepared to carry paclitaxel [PTX] for glutathione (GSH]-regulated drug delivery. The PTX-loaded MPEG-SS-PLA NPs were fabricated using an optimized oil-in-water emulsion/solvent evaporation method. The HPLC results revealed that the NPs released almost 90% PTX within 96 h when GSH presented at intracellular concentrations, whereas only a very small PTX amount was released at plasma GSH levels. The MTT assay results show that the NPs caused concentration- and time-... [Pg.779]

See other pages where Glutathione -responsive polymers is mentioned: [Pg.76]    [Pg.76]    [Pg.235]    [Pg.388]    [Pg.1332]    [Pg.235]    [Pg.288]    [Pg.657]    [Pg.108]    [Pg.368]    [Pg.374]    [Pg.335]    [Pg.38]    [Pg.79]    [Pg.764]    [Pg.778]    [Pg.778]    [Pg.222]    [Pg.1742]    [Pg.87]   
See also in sourсe #XX -- [ Pg.76 , Pg.83 ]



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