Glutathione-Mediated and Other Reactions Involving Nucleophilic Sulfur

Glutathione-Mediated and Other Reactions Involving Nucleophilic Sulfur 

The soluble MMO from Methylococcus capsulatus (Bath) is able to oxidize chloro- and bromomethane—but not iodomethane—with the presumptive formation of formaldehyde (Colby et al. 1977). 

A number of haloalkanes including dichloromethane, chloroform, 1,1-dichloroethane and 1,2-dichloroethane may be degraded by the soluble MMO system of Methylosinus trichosporium (Oldenhuis et al. 1989). 

The metabolism of chloroform has been studied in several organisms (Hamamura et al. 1997), and from the inhibitory effect of acetylene it was concluded that a monooxygenase was involved  

The degradation of 1,2-dichloroethane by Pseudomonas sp. strain DCAl was initiated not by hydrolysis, but by monooxygenation with the direct formation of 1,2-dichloroethanol that spontaneously decomposed to chloroacetaldehyde (Hage and Hartmans 1999). 

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