Glutathione conjugates higher plants

Catabolism of Glutathione Conjugates of Pesticides in Higher Plants... 

The conjugation of xenobiotics with glutathione (GSH) in higher plants was first demtxistrated to be a major enzymatic detoxication mechanism with the atrazine herbicide in sorghum, corn, and other atrazine resistant species (77-80) (Equation 15). Since this... 

Propachlor Is metabolized by this route In both a resistant and a susceptible species (Equation 16). Glutathione conjugation of propachlor occurs very rapidly Un vitro in the absence of GST enzymes (78) and It Is not clear whether differences In GSH and/or GST concentratlois influence the selectivity of propachlor and related herbicides. The concentration of GSH In higher plants Is estimated... 

According to the investigations of Lamoureux et al. (1971), 75% of the propachlor absorbed by higher plants is metabolised within 18 hours to water-soluble glutathione conjugates. 

Figure 9.5 The metabohsm of glutathione and homoglutathione conjugates in higher plants. [Reproduced from G. L. Lamoreux, R. H. Shimabukuro, and D. S. Frear Glutathione and Glucoside Conjugation in Herbicide Selectivity , in J. C. Caseley, G. W. Cussans, and R. K. Atkin, Eds., Herbicide Resistance in Weeds and Crops, Butterworth-Heinemann Ltd., Oxford, pp. 227-262. Copyright 1991, with permission from Elsevier.]...

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