Glutaryl-CoA oxidase

Two other oxidase activities have been described in rat liver peroxisomes, one acting on glutaryl-CoA, the other on valproyl-CoA. The glutaryl-CoA oxidase activity, however, co-purifies with the inducible pahnitoyl-CoA oxidase. The valproyl-CoA oxidase was claimed to differ from the above described acyl-CoA oxidases, but in our hands this activity was recovered mainly in the cytosol (Casteels, M. Van Veldhoven P. P., unpublished data). 

Bennett, M.J., Pollitt, R.J., Goodman, S.I., Hale, D.E. Vamecq, J. (1991)7. Inherit. Metab. Dis. 14, 165-73. Atypical riboflavin-responsive glutaric aciduria, and deflcient peroxisomal glutaryl-CoA oxidase activity a new peroxisomal disorder. 

Glutaric aciduria type III (glutaryl-CoA oxidase deficiency)... 

Apart from glutaric aciduria II (ETF or ETF dehydrogenase deficiency, see Sect. 14.10) a third disorder with peroxisomal glutaryl-CoA oxidase deficiency leading to glutaric aciduria has been described (glutaric aciduria III, see Chap. 24). 

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