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Glutamine synthetase ammonium regulation

Nitrogen metabolism plays a critical role in the biosynthesis of the streptothricin-type antibiotic nourseothricin in Streptomyces noursei [102]. Glutamine synthetase is repressed in this organism by a high concentration of ammonium ions. After the ammonium ion is depleted from the medium, derepression of the enzyme occurs. O-aminobenzoic (anthranilic) acid stimulates nourseothricin production and has a marked effect on regulation of enzymes responsible for nitrogen metabolism [102]. [Pg.968]

The intracellular levels of ammonium ions, in S. noursei, are also influenced by the action of alanine dehydrogenase [102]. Ammonium liberated by alanine oxidation is available for the biosynthesis of glutamine via glutamine synthetase. 0-aminobenzoic acid represses both enzymes while stimulating formation of glutamate dehydrogenase and the antibiotic. Cephalosporin biosynthesis appears to be regulated by the same mechanism [103]. [Pg.968]

See other pages where Glutamine synthetase ammonium regulation is mentioned: [Pg.240]    [Pg.191]    [Pg.1075]    [Pg.1461]    [Pg.1592]    [Pg.163]    [Pg.715]    [Pg.125]    [Pg.272]    [Pg.39]   
See also in sourсe #XX -- [ Pg.84 , Pg.86 , Pg.91 , Pg.181 ]



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