Glutamate overproduction in Corynebacterium

Asakura, Y., Kimura, E., Usuda, Y., Kawahara, Y., Matsui, K., Osumi, T., and Nakamatsu, T. (2007) Altered metabolic flux due to deletion of odhA causes L-glutamate overproduction in Corynebacterium glutamicum. Appl. Environ. Microbiol., 73 (4), 1308-1319. 

AsakuraY, Kimura E, UsudaY, Kawahara Y, Matsui K, Osumi T, et al. Altered Metabolic flux due to deletion of odhA causes I glutamate overproduction in Corynebacterium glutamicum. Appl Environ Microbiol 2007 73 1308-19. 

Kimura E,Yagoshi C, KawaharaY, OhsumiT, Nakamatsu T. Glutamate overproduction in Corynebacterium glutamicum triggered by decrease in the level of a complex comprising dtsR and a biotin-... 

Molecular Mechanisms and Metabolic Engineering of Glutamate Overproduction in Corynebacterium glutamicum... 

Triggers for Glutamic Acid Overproduction in Corynebacterium Glutamicum... 

Shirai T, Fujimura K, Furusawa C, Nagahisa K, Shioya S, Shimizu H. (2007). Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis. Microb Cell Eact, 6, 19. 

Normally amino add synthesis will just satisfy the metabolic demand. In some cases, when the amino add occurs in both biosynthetic and energy production pathways, overproduction of the amino add can take place. This is the case, espedally for L-glutamic add, with Corynebacterium, Brevibacterium, Microbacterium and Arthrobacter. 

Kataoka M, Hashimoto KI, Yoshida M, Nakamatsu T, Horinouchi S, Kawasaki H (2006) Gene expression of Corynebacterium glutamicum in response to the conditions inducing glutamate overproduction. Lett Appl Microbiol 42 471-476 Kawaguchi H, Vertes AA, Okino S, Inui M, Yukawa H (2006) Engineering of a xylose metabolic pathway in Corynebacterium glutamicum. Appl Environ Microbiol 72 3418-3428... 

H. et al (2015) Altered acetylation and succinylation profiles in Corynebacterium glutamicum in response to conditions inducing glutamate overproduction. MicrobiologyOpen, 5, 152-173. 

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