Glutamate glutathione synthesis

This is followed by removal of the glutamic acid and the glycine residues, which is followed by acetylation of the remaining cysteine. Essential amino acids are required for the synthesis of the proteins involved, pantothenic acid for coenzyme A synthesis, and phosphorus for synthesis of the ATP needed for glutathione synthesis. Similar scenarios can be developed for glucuronide and sulfate formation, acetylation, and other phase II reaction systems. 

Reeds RJ., D.G. Burrin., B. Stoll, F. Jahoor, J. Henry and M.E. Frazer, 1997. Enteral glutamate is the preferential precursor for mucosal glutathione synthesis in the piglet. Am. J. Physiol. 273, E408-E415. 

Reeds, P.J., Burrin, D.G., Stoll, B., Jahoor, E, Wykes, L., Henry, J. and Frazer, M.E., 1997. Enteral glutamate is the preferential source for mucosal glutathione synthesis in pigs. Am J Phys 273, E408-E415. 

Glutamate is required for the synthesis of some non-essential amino acids and key compounds such as glutathione. 

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