Substantia nigra glucose utilization

Trugman JM, Wooten GF (1987) Selective D1 and D2 dopamine agonists differentially alter basal ganglia glucose utilization in rats with unilateral 6-hydroxydopamine substantia nigra lesions. J. Neurosci, 7, 2927-2935. 

Fig. 14. Caudate nucleus (A), and nucleus accumbens (B), substantia nigra, pars compacta (C), and substantia nigra, pars reticulata (D). Log dose-response curves of glucose utilization folloiving the intravenous administration of apomorphine. Data are presented as means SEM. (From McCulloch et al, 198Id.)...

Fig. 15. Substantia nigra, pars compacta. Metabolic response to apomorphine (0.5 mg/kg) (expressed as percent change in cerebral glucose utilization from control animals) in four groups of animals which had been pretreated for 21 days with saline (SAL), haloperidol (HAL) (1 mg/kg/day), haloperidol with lithium in diet (Li /HAL), and lithium in diet (Li" ). Data are presented as mean SEM. The response to apomorphine in the animal chronically treated with haloperidol (HAL) differs significantly from that with all other treatments. Glucose utilization in control animals was 56 4 pmol/100 g/ min. (Data from McCulloch, Savaki, Pert, Bunney, and Sokoloff, unpublished.)...

Brown, L. L., and Wolfson, L. L, 1978, Apomorphine increases glucose utilization in the substantia nigra, subthalamic nucleus, and corpus striatum of rat. Brain Res. 140 188-193. 

---