Glucose-sensitive polymers

The amine polymers used to prepare glucose sensitive polymers are heterogeneous. The rate of response is slow because of the slow rate of amine transfer from a hydrophobic phase to the aqueous phase. 

TA Horbett, J Kost, BD Ratner. Swelling behavior of glucose sensitive membranes. In SW Shalaby, AS Hoffman, BD Ratner, TA Horbett, eds. Polymers as Biomaterials. New York Plenum Press, 1984, pp 193-207. 

Fig. 16. Concept of glucose sensitive insulin release system using PVA/poly (NVP-10-PBA) complex system, (polymer capsule type)...

Environmentally Sensitive Polymers as Biosensors The Glucose-Sensitive Membrane... 

Figure 16.7 Sequence of insulin release from pH/temperature-sensitive polymer matrix. Both glucose oxidase and insulin are loaded inside the matrix. The decrease in pH by gluconic acid results in ionization of the polymer, which in turn increases the lower critical solution temperature. This makes the polymer water-soluble, and erosion of the polymer matrix at the surface releases the loaded insulin...

Nakamae K, Miyata T, Jikihara A, and Hoffman AS. Formation of poly(glycosyloxyethyl methacrylate)-concanavalin A complex and its glucose sensitivity. Journal of Biomaterials Science, Polymer Edition 1994 6 79-90. 

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