Glucose-6-phosphatase metabolism, pathways

Fig. 1. Some interrelationships between glucose-6-phosphatase and other enzymes of carbohydrate metabolism [from Nordlie (10) copyright (1968), Academic Press, Inc. Reproduced by permission]. Numbers in parentheses indicate the relative disposition per 100 molecules of glucose phosphorylated of glucose-6-P via four alternate metabolic pathways, according to Ashmore et al. (69). Further details are given in the text.

Figure 11.1 Proposed pathway for hex-ose metabolism of homofermentative LAB (1) and (2) phosphoenolpyruvate (PEP)-dependent sugar phosphotransferase system (PTS) (3) mannitol-specific PTS (4) phospho-glucose isomerase (5) mannitol-1-phosphate dehydrogenase (6) mannitol-1-phosphatase (7) 6-phosphofructokinase (8) fructose-diphosphatase (9) fructose-1,6-diphosphate aldolase (10) triosephosphate isomerase (11) glyceraldehyde-3-phosphate dehydrogenase...

The presence of the glycolytic pathway in adipose tissue is supported by studies of the metabolism of glucose-C. Weber et al. (1960) were unable to detect significant fructose-l,6-diphosphatasc activity, a result suggesting that glycolysis is probably irreversible. These same workers, as well as MacLeod el al. (1960) found essentially no glucose-O-phosphatase activity an inactivity which supports the view that adipose tissue does not release free glucose. The relative recoveries of C in the CO2 produced by adipose... 

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