Glucose autooxidation

S. P. Wolff and R. T. Dean, Glucose autooxidation and protein modification. The potential role of autooxidative glycosylation in diabetes, Biochem. J., 245 (1987) 243-250. 

Improving giycaemic control may not only reduce the rate of non-enzymatic glycosyiation and monosaccharide autooxidation, but lower polyol pathway activity. In addition, it should have a beneficial effect on other haemodynamic and hormonal factors involved in the development of diabetic vascular disease. However, in studies of diabetic retinopathy, rapid control of glucose levels by intensive insulin therapy has been shown to worsen vascular disease initially and it could be postulated that a sudden improvement in retinal blood flow promotes further free-radical damage as part of a reperfusion-ischaemic injury. 

Hunt, J.V., Smith, C.T. and WolflF, S.P. (1990). Autooxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 39, 1420-1424. 

It has been suggested that D-arabino-hexos-2-ulose (205) is formed by metal-catalyzed autooxidation of glucose.410... 

Wells-Knecht, K.J. Zyzak, D.V. Litehfield, J.E. Thorpe, S.R. Baynes, J.W. Mechanisms of antioxidative glyco-sylation Identification of glyoxal and arabinose as intermediates in the autooxidative modification of proteins by glucose. Biochem. 1995, 34, 3702—3709. 

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