Glucokinase structure

S. J. Pilkis, I. T. Weber, R. W. Harrison, and G. I. Bell Glucokinase Structural analysis of a protein involved in susceptibility to diabetes. Journal of Biological Chemistry 269,2192 (1994). 

Figure 37-14. Alternative promoter use in the liver and pancreatic B cell glucokinase genes. Differential regulation of the glucokinase GK) gene is accomplished by the use of tissue-specific promoters. The B cell GK gene promoter and exon 1B are located about 30 kbp upstream from the liver promoter and exon 1L. Each promoter has a unique structure and is regulated differently. Exons 2-10 are identical in the two genes, and the GK proteins encoded by the liver and B cell mRNAs have identical kinetic properties.

Figure 8.2 Co-crystal structure of the GK activator 8.20 bound in the allosteric site of glucokinase (pdb code 1V4S). Key residues from the mutation studies are highlighted.

Selected Novel Glucokinase Activator Structures from Recent Patent Literature... 

Figure 9.32 Structures, EC50 values for the activation of recombinant human enzyme, calculated LogP values, and unbound percentages for a series of glucokinase activators. ...

In the search of novel allosteric glucokinase activators, a docking approach into the enzyme structure generated satisfactory actives only after a refined similarity model against four different known activators was used (Scheme 5.10)... 

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