Glucokinase/Hexokinase isoenzymes

The uptake of glucose into the liver is independent of insulin, but liver has an isoenzyme of hexokinase (glucokinase) with a high K, so that as the concentration of glucose entering the liver increases, so does the... 

Hexokinases, the enzymes that catalyze the phosphorylation of glucose, are a family of tissue-specific isoenzymes that differ in their kinetic properties. The isoenzyme found in liver and p cells of the pancreas has a much higher than other hexokinases and is called glucokinase. In many cells, some of the hexokinase is bound to porins in the outer mitochondrial membrane (voltage-dependent anion channels see Chapter 21), which gives these enzymes first access to newly synthesized ATP as it exits the mitochondria. 

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