Glomerular filtration rate iohexol clearance

Jenkins et al. developed a capillary electrophoresis system for the measurement of iohexol as a marker of the glomerular filtration rate (GFR) with a run time of 5.25 min and a coefficient of variation (CV) of 4.3% at 80 mg L" [121]. The GFR, calculated from the plasma clearance, had a reproducibility of 5.47 %. A similar approach (liquid chromatography-mass spectrometry with positive electrospray ionization after enrichment by solid phase extraction) was applied by Putschew et al. for the determination of iodinated contrast agents in treatment plant effluents and surface waters [118]. 

Jonsson AS, Flodin M, Flansson LO, Larsson A. Estimated glomerular filtration rate (eGFR(CystC)) from serum cystatin C shows strong agreement with iohexol clearance in patients with low GFR. Scand J Clin Lab Invest. 2007 9 1 -9. 

Arvidsson A, Hedman A. Plasma and renal clearance of iohexol A study on the reproducibility of a method for the glomerular filtration rate. Scand J Clin Lab Invest 1990 50 757-6. 

Gaspari F, Perico N, Ruggenenti P, Mosconi L, Amuchastegui CS, Guerini E, et al. Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate. J Am Soc Nephrol 1995 6 257-63. 

BCrutzen E, Back SE, Nilsson-Ehlr I, Nilsson-Ehle P. Plasma clearance of a new contrast agent, iohexol A method for the assessment of glomerular filtration rate. J Lab Clin Med 1984 104 955-61,... 

Aurell M. Accurate and feasible measurements of glomerular filtration rate - is the iohexol clearance the answer. Nephrol Dial Transplant 1994 9 1222-1224. 

DNA sequence The nucleotide sequence data are available from the EMBL, GenBank, and DDBJ Nucleotide Sequence Databases under accession number X52255 Half-life About 20 min (experimentally determined for human cystatin C in rat plasma. The similarity in distribution volume and renal clearance between human cystatin C and acknowledged markers of human glomerular filtration, i.e., iohexol and 51 Cr-EDTA, suggests that the substances are eliminated at the same rate in humans with a half-life of approximately 2 h in individuals with normal renal function)... 

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