Glibenclamide Rifampicin

Slc22a7) Drugs NSAIDs, AZT, MTX, zalcitabine Drugs p-lactam antibiotics, NSAIDs, bumetanide, enalapril, glibenclamide, rifampicin, verapamil... 

Compounds that may diminish the hypoglycaemic effect and thus cause an increase in the dosage requirement of sulphonylurea include rifampicin (Syvalahti et al., 1974). There is a theoretical risk of a diminished hypoglycaemic effect with corticosteroids and with oral contraceptives. It has been stated that the absorption of glibenclamide from the gastrointestinal tract may be reduced if it is taken together with guar gum. 

Oat2 Benzylpenicillin, erythromycin, tetracycline, rifampicin, glibenclamide, tolbutamide, zidovudine, ganciclovir, digoxin, enalapril, verapamil, methotrexate, acetylsalicylic add... 

Neither cimetidine nor rifampicin had any clinically relevant effect on the pharmacokinetics of nicorandil. Nicorandil did not alter the anticoagulant effects of acenocoumarol. Although animal studies surest antagonism of effects, a study in patients found no pharmacodynamic interaction between nicorandil and glibenclamide. Nicorandil may potentiate the hypotensive effects of other vasodilators, tricyclic antidepressants and alcohol. 

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