Glass Transition pharmaceuticals

B. C. Hancock and G. Zografi, The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids, Pharm. Res, 11, 471 (1994). 

Hancock, B.C., Shamblin, S.L., andZogra, G. (1995). Molecular mobility of amorphous pharmaceutical solids below their glass transition temperaturB rm. Res., 12 799-806. 

Fernando A. Alvearex-Ninez, Leonard, M.R., and Crawford, L.F. Glass transition temperature measurement as predictors of the physical stability of a poorly soluble pharmaceutical agent formulated as solid dispersion. AAPS 2002, Toronto, ON. 

To fully understand the performance of amorphous materials, it is necessary to be able to measure the molecular mobility of the samples on interest. This is because at temperatures as far as 50 K below the glass transition temperature, pharmaceutical glasses exhibit significant molecular mobility that can contribute to both chemical and physical instability.The main techniques that have been developed for monitoring molecular motions in amorphous materials are nuclear magnetic resonance (NMR) and calorimetric techniques (e.g., DSC and isothermal microcalorimetry). Average molecular relaxation times and relaxation time distribution functions obtained from these... 

A large number of cellulose derivatives have been studied for food as well as for pharmaceutical applications The measurement of the glass transition... 

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