Glass particle shedding

The major problem with all glass ampoules is that when glass is cut there is a phenomenon of glass particle shedding. It is also difficult to fill any heat sensitive product when the temperatures might be >1000°C locally in the neck area. 

These ceramic membranes are relatively easy to operate for filtering particulates. The pressure drop across the thickness of a membrane element and the gas flow rate follows a linear or nearly linear relationship. It has been found, however, that not all inorganic membranes are suitable for clean room air filtration. Glass membranes, for example, suffer from the problem of particle shedding under mechanical shock conditions [Jensen and Goldsmith, 1987]. Sometimes high moisture content in the filtered air can be a problem. Some chemical treatments to ceramic membranes prior to their utilization as... 

Glass remains the preferred material for parenteral pharmaceutical packaging. Glass requires lubrication, cuid silicone oil due to its physicochemical properties fulfills the criteria of a preferred material. External lubricants inherently are hydrophobic and the substitute for siheone oil can also denature the protein at the lubricant/water interface. Additionally, if similar amount of lubricant (as for siheone oil) would be needed to get optimum lubrication, shedding of the particles may still remain a problem. Therefore, until glass is used as a container with silicone lubrication, it is important to understand the protein-silicone oil interactions cuid find solutions to minimize them. 

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