Ginger thromboxane inhibition

Ginger, which inhibits thromboxane synthase and decreases the rate of platelet aggregation, may increase bleeding time. Feverfew, which also inhibits platelet activity, should also be avoided. 

Platelet Inhibition Ginger extract has been found to inhibit platelet aggregation induced by arachidonic acid, epinephrine, ADP, and collagen (Srivastava 1984). The extract s ability to inhibit cyclooxygenase activity and thromboxane levels correlated well with inhibition of platelet aggregation (Srivastava 1984 Mustafa et al. 1993). The type of preparation used also affects platelet inhibition, because roasted and charcoal of ginger were effective, while ether extracts of raw and dried ginger were not (Wu et al. 1993). 

Backon, J. Ginger Inhibition of thromboxane synthetase and stimulation of prostacyclin relevance for medicine and psychiatry. Med Hypotheses 1986 20(3) 271-278. 

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