Gewald synthesis of 2-acyl amino thiophenes

Hoener, A.P.F., Henkel, B. and Gauvin, J.C., Novel one-pot microwave-assisted Gewald synthesis of 2-acyl amino thiophenes on solid support, Synlett, 2003, 63-66. 

Another interesting multi-component reaction is the Gewald synthesis leading to 2-amino-3-acyl thiophenes (Scheme 7.25), which are of current interest since they are commercially used as dyes, conducting polymers and have shown extensive potential for pharmaceutical purposes. 

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