Geriatric patient drug elimination

Three agents are available ondansetron, granisetron, and dolasetron. The drugs have a long serum half-life of 4-9 hours and may be administered once or twice daily by oral or intravenous routes. The drugs undergo extensive hepatic metabolism and are eliminated by renal and hepatic excretion. However, dose reduction is not required in geriatric patients or patients with renal insufficiency. For patients with hepatic insufficiency, dose reduction may be required with ondansetron. 

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