Genomic footprinting

Huibregtse, J. M., and Engelke, D. R. (1989). Genomic footprinting of a yeast tRNA gene reveals stable complexes over the 5 -flanking region. Mol. Cell. Biol. 9, 3244-3252. 

Dolle, A. Stratling, W.H. (1990). Genomic footprinting of proteins interacting with the chicken lysozyme promoter. Gene 95, 187-93. 

In this chapter we give a detailed description of the methodology Involved In genomic footprinting with emphasis upon DMS (dlmethylsulfate) reactivity experiments In Intact mammalian cells. The experimental conditions described rely on the pioneering work of Church, Ephrussl and Gilbert (11,19,23) with modifications and Improvements added more recently (20,22). 

In Vivo Genomic Footprinting with Dimethyl Sulfate... 

An example of genomic footprinting of avian vitellogenin II gene is shown in Fig. 3. In cases where the genome size exceeds 5 X 10 bases per haploid genome, it may be necessary to first enrich the sequence of interest prior to the piperidine reaction (see Mirkovitch and Darnell, 1991). 

Saluz, H. P., and Jost, J. P. (1989b) Genomic footprinting with Taq polymerase. Nature 338,... 

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