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Genomes human, P450 enzymes

Hydroxylation is the chief reaction involved in phase 1. The responsible enzymes are called monooxygenases or cytochrome P450s the human genome encodes at least 14 families of these enzymes. Estimates of the number of distinct cytochrome P450s in human tissues range from approximately 35 to 60. The reaction catalyzed by a monooxygenase (cytochrome P450) is as follows ... [Pg.626]

As with some of the other P450s, the only knowledge currently available is the existence of the CYP27CI gene in the human genome. Suggestions that this enzyme is involved in vitamin D metabolism are still only speculatory. [Pg.460]

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See also in sourсe #XX -- [ Pg.347 , Pg.378 ]



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