Genetic Haemochromatosis

On the basis of a number of physico-chemical methods (Mossbauer spectroscopy, electron diffraction, EXAFS) the iron cores of naturally occurring haemosiderins isolated from various iron-loaded animals and man (horse, reindeer, birds and human old age) were consistently shown to have ferrihydrite-like iron cores similar to those of ferritin (Ward et ah, 1992, 2000). In marked contrast, in the tissues of patients with two pathogenic iron-loading syndromes, genetic haemochromatosis and thalassaemia, the haemosiderins isolated had predominantly amorphous ferric oxide and goethite cores, respectively (Dickson etah, 1988 Mann etah, 1988 ... 

Cundy, T., Butler, X, Bomford, A., Williams, R. Reversibility of hypo-gonatotrophic hypogonadism associated with genetic haemochromatosis. Clin. Endocrin. 1993 38 617-620... 

Hiibscher, S.G. Iron overload, inflammation and fibrosis in genetic haemochromatosis. (editorial) J. Hepatol. 2003 38 521 -525... 

Britto, M.R.C., Thomas, LA., Balaratnam, N., Griffiths, A.P., Duane, P.D. Hepatocellular carcinoma arising in non-cirrhotic liver in genetic haemochromatosis. Scand. J. Gastroenterol. 2000 35 889-893... 

Goh J, Callagy G, McEntee G, O Keane JC, Bomford A, Crowe J. Hepatocellular carcinoma arising in the absence of cirrhosis in genetic haemochromatosis three case reports and review of literature. Eur J Gastroenterol Hepatol 1999 11(8) 915-19. 

Phelps, G., Hall, P., Chapman, I., Braund, W., and McKinnon, M., 1989, Prevalence of genetic haemochromatosis among diabetic patients. Lancet 1 233-234. 

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