Generation of the Code

The two values, e and s, calculated for all the combinations of four atoms (each one sampled from a different ligand of a chiral center) are then combined to generate a conformation-independent ckirality code, fcjcC rising Eq. (28). 

The number of discrete points of /cicc( ) determines the resolution of the chirality code is a smoothing factor which in practice controls the width of the peaks obtained by a graphical representation versus u. An example of a chir- 

Applications of the CICC to the prediction of enantiomeric preference in enan-tiosclcctivc reactions arc described in ref s, [37] and [42.  

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