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Generation of Carbanions on Solid Supports

Reactions involving reversibly formed carbanions may require much weaker bases, especially when there is stabilization by EWGs. [Pg.314]

Alternatively, carbanion equivalents may be formed by the polarization of organic substrates by suitable Levds acids. Stringent Levds acidic conditions may [Pg.314]

Hydrazine linker on Merrifield resin was reacted with various aldehydes, affording the corresponding hydrazones. 1,2-Addition of various organometallics to the supported hydrazones was investigated. [Pg.315]

A comparative study revealed organoli-thiums as the reagents of choice. Reductive cleavage afforded a-branched amines. [Pg.315]

Chiral hydrazines, supported on Merri-field resin, were reacted with various aldehydes, affording the corresponding hydrazones. These compounds allowed stereoselective preparation of a-branched amines, through 1,2-addition of both aromatic and aliphatic nucleophiles to the C=N double bond of the hydrazones. Reductive cleavage released the desired amine from the resin. Moderate to good enantiomeric excesses (50-86%) were achieved. [Pg.315]

See other pages where Generation of Carbanions on Solid Supports is mentioned: [Pg.315]    [Pg.317]    [Pg.319]    [Pg.321]    [Pg.325]    [Pg.327]    [Pg.329]    [Pg.331]    [Pg.333]    [Pg.335]    [Pg.339]    [Pg.315]    [Pg.317]    [Pg.319]    [Pg.321]    [Pg.325]    [Pg.327]    [Pg.329]    [Pg.331]    [Pg.333]    [Pg.335]    [Pg.339]    [Pg.486]    [Pg.370]    [Pg.314]    [Pg.465]   


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Carbanions generation

Carbanions solid supports

Generation of Carbanion

Generation of carbanions

On solids

Solid support

Solid-supported

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