Generation of ATP in Anaerobic Glycolysis

The sequence of reactions by which glucose is broken down to lactic acid in the animal body has been thoroughly worked out, and most of the enzymes involved have been isolated in crystalline form and subjected to study in detail. Several excellent reviews have presented a complete picture of the glycolytic pathway, and details need not be repeated here. Instead, ouf attention will be directed to two stages only in this process, the two enzymatic steps which involve the production of ATP. 

The first reaction is the oxidation of 3-phosphoglyceraldehyde. This reaction has been studied by Warburg and his school, who discovered 

Dickens in Sumner and Myrback, The Enzymes, Academic Press, New York, 

Lardy in Lardy, Respiratory Enzymes, Burgess Publishing Co., Minneapolis, 1949, p. 179. 

3-diphosphoglyceric acid then transfers its high-energy phosphate to ATP by the next reaction in the sequence  

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