Generalised born

In the generalised Born approach the total electrostatic energy is written as a sum of tin terms, the first of which is the Coulomb interaction between the charges in vacuo ... 

The generalised Born equation has been incorporated into both molecular mechan calculations (by Still and co-workers [Still et al. 1990 Qiu et al. 1997]) and semi-empiri quantum mechanics calculations (by Cramer and Truhlar, in an ongoing series of mod called SMI, SM2, SM3, etc. [Cramer and Truhlar 1992 Chambers et al. 1996]). In th( Ireafirients, the two terms in Equation (11.61) are combined into a single expression of 1 following form ... 

Jorgensen WL, Uhnschneider JP, Tirado-Rives J. (2004) Free energies of hydration firom a generalised Born model and an all-atom force field. J Phys Chem B 108 16264-16270. 

Zhu J, Alexov E, Honig B. (2005) Comparative study of generalised Born models Born radii and peptide folding. J Phys Chem B 109 3008-3022. 

It should be borne in mind that although it is possible to generalise on sampling procedures, all industries have their own established methods for obtaining a record of the quantity and/or quality of their products. The sampling procedures for tobacco leaves will obviously differ from those used for bales of cotton or for coal. But although the types of samples differ considerably the actual analytical methods used later are of general application. 

While the results are far from conclusive, and the danger of generalising must be borne... 

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