General Interaction Properties Function descriptors

A more complex approach in QSRR is the description of the retention behavior of solutes by a multiparameter equation that includes several descriptors related to different structural properties. Chromatographic retention data must be some function of the chemical structure of solutes, stationary phase and mobile phase, all of them mutually interacting. However, there is no general, strict, canonical nation relating the retention to these variables. Even if the stationary and mobile phases in a given chromatographic system remain constant, still a precise quantitative description of the retention of a series of solutes appears problematic, and the difficulties increase with the diversity of the solutes consider. The problem is also not trivial for homologues. 

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