General Conclusion on Antibody Separation Technologies

In spite of the large amount of resources spent at the research level for a number of years, disappointing therapeutic results prevented the commercial development of therapeutic antibodies. Because of their high specificity, they therefore have heavily supported the diagnostic development with numerous applications. [Pg.620]

Today biochemists have a complete set of recipes and tool boxes to obtain very pure antibodies. The use of what exists in a rational and effective [Pg.620]

Neuberger, M. S., Williams, G. T., Mitchell, E. B., Jouhal, S. S., Flanagan, J. G., and Rabbitts, T. H. (1985). A hapten-specific chimaeric IgE antibody with human physiological effector function. Nature, (London) 314, 268-270. [Pg.621]

Winter, G., Griffiths, A. D., Hawkins, R. E., and Hoogenboom, H. R. (1994). Making antibodies by phage display technology. Annu. Reu. Immunol. 12, 433-455. [Pg.621]

Winter, G. (1998). Synthetic human antibodies and a strategy for protein engineering. FEBS Lett. 430, 92-94. [Pg.621]

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