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General Concepts on Antimicrobial Therapy

Pharmacokinetic and pharmacodynamic properties should be incorporated into the selection of antibiotics for the treatment of nosocomial pneumonia (12). [Pg.95]

Marcel Dekker Inc. 270Madison Avenue, New York, New York 10016 [Pg.95]

P-lactamase inhibitors Overproduction of P-lactamase new P-lactamases chromosomal cephalosporinases [Pg.96]

Cephalosporins Extended spectrum P-lactamases chromosomal P-lactamases (AmpC) plasmid P-lactamases (TEM-1, SHV-1) [Pg.96]

Quinolones Alterations in DNA topoisomerase, efflux mechanisms, permeability changes [Pg.96]

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