Gene expression, drugs effect

Drugs of abuse have profound effects on transcription factors and gene expression. These effects are clearly important for long-lasting changes in brain function. Two transcription factors strongly implicated in addiction are CREB and AFosB [23], CREB is important for learning and memory and is activated by phosphorylation. 

Gardner-Stephen, D., Heydel, J. M., Goyal, A., Lu, Y., Xie, W., Lindblom, T., Mackenzie, P., and Radominska-Pandya, A. (2004) Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression. Drug Metab. Dispos. 32, 340-347. 

O Differential effects of compounds - in vivo or in vitro - on gene expression, among the entirety of expressed genes O Assessed by expression profiling O A tool for compound selection/drug discovery... 

Drugs of abuse have profound effects on transcription factors and gene expression 924... 

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