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Gene delivery polysaccharides

Yudovin-Farber I, Domb AJ (2007) Cationic polysaccharides for gene delivery. Mat Sci Eng 27 595-598... [Pg.183]

Azzam T, Raskin A, Makovitzki A et al (2002) Cationic polysaccharides for gene delivery. Macromolecules 35(27) 9947-9953... [Pg.183]

In another study, dendritic amidoamine side chains of different generations were covalently attached to the polysaccharide chitosan in an attempt to combine the biological activity of chitosan in gene delivery. [Pg.602]

Toita, S. Sawada, S. Akiyoshi, K. Polysaccharide nanogel gene delivery system with endosome-escap-ing function Co-delivery of plasmid DNA and phospholipase A2. J. Control. Release 2011, 155 (1) 54-59. [Pg.1309]

Ouchi, T., Murata, J-I. and Ohya, Y. (1999) Gene delivery by quaternary chitosan with antennary galactose residues, in Polysaccharide Applications Cosmetics and Pharmaceuticals (eds M.A. El-Nokaly and H.A. Soini), American Chemical Society, Washington DC, pp. 15-23. [Pg.87]

Figure 9.1 Mechanism of gene delivery using cationic polysaccharides. (A) Polyplex formation. (B) Entry of polyplex into the cell via endocytosis. (C) Endosomal escape. (D) Entry of DNA inside the nucleus. (E) Gene expression. Figure 9.1 Mechanism of gene delivery using cationic polysaccharides. (A) Polyplex formation. (B) Entry of polyplex into the cell via endocytosis. (C) Endosomal escape. (D) Entry of DNA inside the nucleus. (E) Gene expression.
The most commonly used cationic polysaccharides in gene delivery, such as chitosan, CD, dextran, carbohydrate copolymers, etc., are discussed exhaustively in this section. The chemical structures of the listed pol3miers are given in Figure 9.2. [Pg.231]

For gene delivery applications, cationic polymers that form complexes with nucleic acids through electrostatic interactions are often used as non-viral vectors that provide protection of DNA from enzyme degradation and facilitate cellular uptake. Monosaccharides or polysaccharides have been well studied for the production of low-toxicity gene delivery vectors. [Pg.209]


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