Gemfibrozil side effects

As described above, the outcome data with fibrates is mixed. Gemfibrozil is the fibrate with the best outcome data but should not be combined with a statin as it can increase plasma levels of all statins and therefore the risk of severe side effects. If the major abnormality is a high LDL-cholesterol, gemfibrozil will have little impact. Bezafibrate has a better impact on LDL as well as increasing HDL-cholesterol and decreasing triglyceride but the clinical benefits from RCTs relate only to post hoc analyses. 

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